Alzheimer's disease has turned out to be six different diseases.

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<pre>Alzheimer's disease has turned out to be six different diseases.

A new study with the participation of many international experts has shown that Alzheimer's disease as a separate disease was a mistake. There are at least six different cognitive symptoms, the evaluation of which should not be reduced to a single diagnosis. Because of this, diagnostic and treatment methods are ineffective – instead of affecting the problem, doctors struggled with ephemeral “disease.” And if it was possible to choose a drug against one of them, then the clinical studies failed when the next patient had another problem. We had to re-examine and rethink the state of 4000 patients to find out: in addition to early and late Alzheimer's, there are also diseases of the same name of language, memory, executive function of the brain, and spatial-visual function.

In 39% of patients, problems were found in all four new cognitive zones, but in 27% there were sharp differences in the assessment of the state of memory – it was almost in order. The remaining patients were divided into small groups of 5-6%, in each of which anxious symptoms were observed only in two cognitive zones, but these couples differed everywhere. Scientists conducted a study of the genome of patients and, to their surprise, found 33 markers that clearly separated them into six cognitive domains.

This is not just a rethinking of the concept of Alzheimer's disease, but a small revolution in medicine. Now we know about the existence of six ways of developing the disease, each with its own pronounced set of symptoms and a genetic “signature”, which allows us to develop case studies in new directions. And start diagnosing the disease and treating people many times more precisely than before.

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