Scientists successfully implanted tiny human brains in mice

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<pre>Scientists successfully implanted tiny human brains in mice

Scientists from the University of Salk (USA) reported on a breakthrough in working with brain organoids, whose lifetime has now become almost unlimited. They managed to solve the problems of supplying cells with oxygen and nutrients throughout the entire volume of the organoid, without the death of individual sites. To do this, the researchers implanted the human brains in laboratory mice and they successfully took root there.

Brain organoids are artificial structures grown from stem cells that mimic the human brain in miniature. They were first created in 2013, and today scientists can grow a variety of types of organelles to study pathologies, developmental anomalies, the consequences of injuries and brain effects on various factors. An important problem was the provision of their livelihoods – even in a special nutrient environment organelles survived no longer than 5 weeks.

Experts from the University of Salk decided to use the ready, nature-created life-support system for the brain of laboratory mice, for which they cut out a fragment the size of a lenticular grain and replaced it with an organoid, closing the place of the cut with a transparent window. Approximately 80% of all implants successfully took root and after the 12th week even began to grow completely new neurons, adapting to the environment. The record of the life of human organelles in the brain of the mouse was 233 days!

As soon as the survival of organelles became apparent, a question immediately emerged from the field of bioethics: we created a human mouse? How will the creature behave with a part of the brain of a different, highly developed species? The answer: no way, the mice remained mice and on all tests showed the same results as their non-operated relatives. Rodents perform only the function of an incubator, a living plant for growing organoids – a new kind of creature can not be obtained in this way.

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