Researchers from the California Institute of Technology developed a technique for manipulating DNA molecules to assemble arbitrary structures from them. a small copy of the famous Da Vinci picture in the world.It has a mosaic structure and consists of 64 separate fragments which are obtained by the DNA-origami method
DNA origami technology was developed in 2006. It is based on the property of nucleotides, small molecules A, T, C and G, which are strung in nnuyu strand DNA macromolecule, interconnected in strict order. And if “play” with their location on the filament, then it will be possible to roll it into a ball shape or any other stable structure in contrast to the classical double-stranded DNA helix.
A group of scientists led by Gregory Tikhomirova developed a technology of “fractal assembly” on the basis of DNA origami. a lot of “squares” of properly folded DNA molecules, and then they are laid out on the substrate in a given order, forming a pattern.It sounds simple, but in reality, scientists have solved the most complex task of minimizing the cost of synthesis and manipulation of individual DNA.
The method of the Tikhomirov group has one more advantage: images from DNA can be easily scaled. The assortment of basic “squares” is small, but this is what made the process of “drawing” relatively cheap and affordable. An online tool is already ready, which will allow other scientists to compose their own schemes for later drawing on them using DNA. About the practical application of technology so far nothing is known.